Exposición a la luz nocturna, disrupción del ritmo circadiano y la obesidad

La obesidad es una condición patológica caracterizada por la acumulación de exceso de tejido adiposo y está asociada con enfermedades de severidad variable como: diabetes mellitus, enfermedades cardiovasculares, hipertensión arterial, asma, cáncer y trastornos de la función reproductora. Además de los riesgos tradicionales en la presentación de la obesidad con la dieta hipercalórica y la vida sedentaria, existen otros factores ambientales responsables del desarrollo de esta entidad y de su mantenimiento.

1. Caballero B. The global epidemic of obesity: an overview. Epidemiol Rev. 2007; 29:1-5.
2. Symonds ME, Sebert B, Budge H, The obesity epidemic from the environment epigenetics- no simply a response to direct manipulation in a thermoneutral environment. Front Genet. 2001; 2:24.
3. National Academy of Engineering. Greastest engineering achievements of the 20th century. Engineering. 2000. Http:/www.greatest achievement.org/.
4. Fonken LK, Nelson RJ. Iluminating the deleterious effect of light at night. F100 Med Rep. 2001;13-18.
5. Navarra KJ, Nelson RJ. The dark side of light at night: phsiological, epidemiological, and ecological consequences. J Pineal Res. 2007; 43(3): 215-224.
6. Laura K, Fonken and Randy J Nelson. The effects of light at night on circadian clocks and metabolism. Endocrine Rev. 214; 35:648-670.
7. Gerhart- Hinces Z, Lazan A M. Circadian metabolism in the light evolution. Endocrine Rev. 2015; 36:289-304.
8. Ashoff J. Circadian rhythms in man.Science. 1965; 148 (3676): 1427-1432.
9. Ruby NF, Burns DE, Hellen HC. Circadians rhythms in the suprachiasmatic nucleus are temerature-copensated and phase- shited by heat pulses in vitro. J Neurosci. 1999; 19 (9): 8630-8636.
10. Ralph MR, Menaker M. A mutation of circadian system in golden hamsters. Science. 1988; 241 (4870): 1225-1227.
11. Takahashi JS, Hong HK, Ko CH, et al. The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet. 2008; 9 (10): 764-775.
12. Zee PC, Attarian H, Videnovic A. Circadian rhytm abnormalities. Continuum. 2013; 191 (sleep disorders): 132-147.
13. Van den Pol AN. The hypothalamic suprachiasmatic nucleus of rat: intrinsic anatomy. J Comp Neurol. 1980; 191 (14) : 661-702.
14. Lydic R, Albers HE, Tepper B, et al. Three dimensional structure of the mammalian suprachiasmatic nuclei: a comparative study of five species.J Comp Neurol. 1982; 201 (3): 225-237.
15. Lydic R, Schoene Wc, Czeisler CA, et al. Suprachiasmatic region of the human hypothalamus: homolog to the primate circadian pacemaker? Sleep. 1980; 2 (3): 355-361.
16. Rusak B, Groos G. Suprachiasmatic stimulation phase shifts rodents circadian rhytms. Science. 1982;215 (4538): 1407-1409.
17. Reddy AB, Maywood ES, Karp NA, et al. Glucocorticoid signaling synchronizes the liver circadian transcriptome. Hepatology. 2001; 45 (6): 1478-1488.
18. McNamara P, Seo SB, Rudic RD, e al. Regulation of CLOCK and MOP4 by nuclear hormone receptores in the vasculature: a humoral mechanism to reset a periphenal clock. Cell. 2001;105(7): 877-889.
19. Guo H, Brewer JM, Champhekar A, et al. Differential control of preripheral circadian rhytm by suprachiasmati-depend neural signals. Proc Natl Acad Sci USA. 2005;102 (8): 3111-3116.
20. Wright KP Jr, McHill Aw Birks BR, et al. Entrainment of the human circadian clock to the natural light-dark cycle. Curr Biol. 2013; 23 (16): 1554-1558.
21. Eckel-Maham KL, Sassone-Corsi P, et al. Coordination of the transcriptome and metabolome by the circadian clock. Proc Natl Acad Sci USA. 2012; 109(14): 5541-5546.
22. Scheer FA, Morris CJ, Shea SA. The internal, circadian clock increases hunger and apetite in the evening independent of food intake and other behaviors. Obesity. 2013; 21 (3): 421-423.
23. Lee A, Ader M, Bay GA, et al. Diurnal variation in glucose tolerance. Ciclic suppression of insulin action and insulin secretion in normal- weight, but no obese subjects. Diabetes. 1992;41(6):750-79.
24. Baron KG, Reid KJ, Kern AS, et al. Role of sleep timing in caloric intake and BMI. Obesity. 2011;119 (7): 1374-1381.
25. Baron KG, Reid KJ, Kern AS, et al. Contribution of evening macronutrients intake to total caloric intake and body mass index. Apetite. 2013;60(1): 246- 251.
26. Jakubowicz D, Barnes M, Wainstein J, et al. High caloric intake at breakfast versus dinner differentialty influences weigth loss of overweight and obese women. Obesity (Silver spring). 2013;21 (12): 2504-2512.
27. Wang XS, Armstrong ME, Cairns BJ, et al. Shift Work and chronic disease: The epidemiologcal evidence. Occups Med. 2010;67(1):54-57.
28. Pietroiusti A, Nery A, Soma G, et al. Incidence of metabolic síndrome among night-shift healthecare Workers. Occups Environ Med. 2010;67(1):54-57.
29 Sookian S, Gemma G, Fernandez Gianotti, et al. Effects of rotating shift work on biomarkers of metabolic síndrome and inflamation. J Intern M. 2007;261 (3): 285-292.
30. Esquirol Y, Bongard V, Mabile L, et al. Shift work and metabolic sydromre: respective impacts of job strain, thypical activity , and dietary rithms. Chronobiol Int. 2009; 26 (3) 544-559.
31. De Bacquer D, Van Risseghem M,et al. Rotating shift wok and th metabolic síndrome; a prospective study. Int J epidemol. 2009;26(3): 544-559.
32. Lin YC, Hsiao TJ, Chen PC. Persistent rotating shift work exposure accelarates development to metabolic sydrome among middle-aged females employees: a fice years follow up. Cronobiol Ind. 2009;26 (4): 740-755.
33. Monk TH. Shift Work. In: Kryger MH, Roth T, Dement WC, eds. Principles and practice of Sleep Medicine. Philaldephia, PA: WB Saunders; 2000:471-476.
34. Reiter RJ. Melatonin: The chemical expresión of darkness. Mol Cell Endocrinol. 191;791 (1-3): C153-C158.
35. Brainard GC, Lewy Aj, Menaker M, et al. Dose-response relationship between light irradiance and the suppression teens. Brain Res. 1988; 454 (1-2): 212- 218.
36. Brainard GC, Rollag MD, Hanifin JP. Photic regulaton of melatonin in human: ocular and neural signal transduction. J Biol Rhytsms. 1997;12(6): 537-546.
37. Nduhirabandi F, du Toit EF, Lochner A. Melatonin and the metabolic sydrome: a tool for effective therapy in obesity associated abnormalities? Acta Physiol. 2012; 205(2): 209-233.
38. Reiter RJ, Tan DX, Korkamaz A, MaS. Obesity and metabolic síndrome: association with chronodisruption, sleep deprivation and melatonin suppression. Ann Med. 2012; 44(6) 564-577.
39. McMullan CJ, Schernhammer ES, Rimm ES,et al. Melatonin secretion and the indcende f thype 2 diabetes. JAMA, 2013;309 (13):1388-1396.
40. Kayumov L, Casper RF, Hawa RJ, et al. Blocking low wavelenght light prevents nocturnal melatonin suppresion with no adverse effect on perfomance during simulated shift work. J Clin Endocrinl Metab. 2005;90(5): 2755-2761.

ritmo circadiano
obesidad